An article published this year in “ScienceDirect” using one of our products, “FITC AnnexinV”, by our customers from Laboratory of Tumor Molecular Immunobiology, Ludwik
Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland,
in the analysis of how Enantiomeric trans β-aryl-δ-iodo-γ-lactones
derived from 2,5-dimethylbenzaldehyde induce apoptosis in canine lymphoma cell
lines by downregulation of anti-apoptotic Bcl-2 family members Bcl-xL and Bcl-2.
Congrats and Thanks.
Summay:
For many years, studies focused
on developing new natural or synthetic compounds with antineoplastic activity
have attracted the attention of researchers. An interesting group of such
compounds seem to be those with both lactone moiety and an aromatic ring which, in
addition to antimicrobial or antiviral activity, also exhibit antitumor properties. The study shows antitumor activity of two enantiomeric trans isomers of
5-(1-iodoethyl)-4-(2′,5′-dimethylphenyl)dihydrofuran-2-one. Our aim was to
determine their antitumor activity manifested as an ability to induce apoptosis in selected
canine cancer cell lines as well as to evaluate differences in their strength depending on
the configuration of their stereogenic centers. The enantiomers (+)-(4R,5S,6R)-1 and (−)-(4S,5R,6S)-2 were found to induce classical
caspase-dependent apoptosis through downregulation of the expression of anti-apoptotic proteins Bcl-xL and Bcl-2. Although the mechanism of apoptosis induction was the same for both
enantiomers, they differed in their strength, as stronger antineoplastic
activity in vitro was exhibited by isomer (+)-(4R,5S,6R)-1.
Reference:
Product link:
FITC AnnexinV
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